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The effect of rice bran extract and aerobic exercise on oxidative stress indices of white adipose tissue in obese rats
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Mojtaba Moazami Goodarzi1   , Shahram Gholamrezaei  2, Mohammad Ali Azarbayjani3 , Alireza Elmieh1 |
1- Department of Exercise Physiology, Rasht Branch, Islamic Azad University, Rasht, Iran
2- Department of Exercise Physiology, Rasht Branch, Islamic Azad University, Rasht, Iran , gholamrezaei@iaurasht.ac.ir
3- - Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran |
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Abstract: (386 Views) |
Background: Evidence suggests that oxidative stress is one of the main mechanisms that causes the effects of obesity. Physical activity and the use of medicinal herbs are two effective ways to control oxidative stress in obese conditions. Although several studies have been performed on the effect of aerobic exercise and herbs on oxidative stress markers, the simultaneous effect of aerobic exercise and rice bran extract on oxidative stress markers in white adipose tissue is not known. Therefore, the aim of this study was to develop the effect of aerobic exercise and rice bran extract on the amount of SOD, CAT and MDA concentrations of white adipose tissue in rats fed a high-fat diet.
Materials and methods: In a pre-clinical trial, 30 female Wistar rats were selected as experiments and randomly divided into five groups of healthy control, control fed high fat diet, fed high fat diet with aerobic exercise, fed high fat diet with rice bran extract and fed high-fat diet with aerobic exercise-rice bran extract. Palm frying oil was used to induce obesity. The aerobic exercise program consisted of running on a treadmill for four weeks and five sessions a week. Rice bran extract also included receiving 60 mg per kilogram of body weight for 4 weeks and 5 times a week by gavage. At the end of the course, white adipose tissue was removed to determine the amount of SOD, CAT and MDA after sacrificing the subjects.
Results: High fat diet significantly reduced SOD (P= 0.001) and catalase (P= 0.001); While significantly increased MDA values (P= 0.001). Aerobic exercise significantly increased SOD and CAT but had no effect on MDA. While, rice bran extract significantly increased SOD and CAT and decreased MDA. The interaction of exercise and rice bran on the study outcomes was not significant.
Conclusion: Since aerobic exercise and rice bran reduce the oxidative stress of white adipose tissue, it is suggested that in the context of high fat diet, these two interventions can be used to reduce the side effects of high fat diet.
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| Keywords: SOD, CAT, MDA, Aerobic exercise, Rice bran |
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Full-Text [PDF 334 kb]
(178 Downloads)
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Semi-pilot: Experimental |
Subject:
Physiology
Received: 2022/09/5 | Accepted: 2022/10/10 | Published: 2023/12/1
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Moazami Goodarzi M, Gholamrezaei S, Azarbayjani M A, Elmieh A. The effect of rice bran extract and aerobic exercise on oxidative stress indices of white adipose tissue in obese rats. MEDICAL SCIENCES 2023; 33 (4) :347-354 URL: http://tmuj.iautmu.ac.ir/article-1-2033-en.html
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